Clinical UM Guideline

Subject: Non-Obstetrical Transvaginal Ultrasonography
Guideline #:  CG-MED-56 Current Effective Date:    03/29/2017
Status: New Last Review Date:    02/02/2017


This document addresses the use of non-obstetrical transvaginal ultrasonography for the evaluation of conditions of the pelvis and surrounding tissues.

Note: This document does not address the use of transvaginal ultrasonography for infertility-related conditions and treatments.

Clinical Indications

Medically Necessary:

  1. Non-obstetrical transvaginal ultrasonography is considered medically necessary to evaluate or guide treatment for any of the following conditions:
    1. Abnormal uterine or vaginal bleeding; or
    2. Amenorrhea, delayed menses, or dysmenorrhea; or
    3. Congenital uterine or lower genital tract anomalies; or
    4. Endometriomas or endometriosis, including deeply infiltrating endometriosis of the rectum or rectovaginal septum; or
    5. Excessive bleeding, pain, or signs of infection after pelvic surgery; or
    6. Follow-up of a previously detected abnormality of the pelvis or surrounding tissues; or
    7. Incontinence or pelvic organ prolapse; or
    8. New onset of symptoms such as abdominal or pelvic pain, bloating, early satiety, or urinary frequency and urgency, and an abnormal abdominal or pelvic examination is suspicious for gynecologic cancers; or
    9. Pelvic infection or pelvic inflammatory disease (such as, tubo-ovarian abscess, hydrosalpinx, or pyosalpinx); or
    10. Pelvic masses, benign or malignant (such as, adenomyosis, fibroids, cancers of the ovaries, vagina, uterus, or other pelvic structures); or
    11. Polycystic ovarian syndrome.
  2. Non-obstetrical transvaginal ultrasonography is considered medically necessary to monitor for endometrial or ovarian cancer in individuals with hereditary breast and ovarian cancer syndromes (HBOC), Lynch syndrome, or Peutz-Jeghers syndrome.
  3. Non-obstetrical transvaginal ultrasonography is considered medically necessary to confirm the position of an intrauterine contraceptive device if the device string is not visible or there is a suspicion that the device is incorrectly positioned within the uterus.  

Not Medically Necessary:

Transvaginal ultrasonography is considered not medically necessary when criteria are not met and for all other indications, including routine screening for gynecologic cancers (such as, endometrial or ovarian cancer).


The following codes for treatments and procedures applicable to this guideline are included below for informational purposes. Inclusion or exclusion of a procedure, diagnosis or device code(s) does not constitute or imply member coverage or provider reimbursement policy. Please refer to the member's contract benefits in effect at the time of service to determine coverage or non-coverage of these services as it applies to an individual member.

76830 Transvaginal ultrasound [non-obstetrical]
ICD-10 Diagnosis  
  All diagnoses
Discussion/General Information

Transvaginal ultrasonography (TVU), also referred to as endovaginal ultrasonography, is an imaging procedure and type of pelvic ultrasound technique which uses a thin transducer (ultrasound probe) covered with conducting gel and a plastic/latex sheath that is inserted about two to three inches into the vaginal canal. While the probe may be temporarily uncomfortable, TVU is essentially a painless procedure. TVU allows rapid visualization and detailed images of the pelvic organs including the cervix, fallopian tubes, ovaries, uterus, and vagina and surrounding structures. No ionizing radiation (x-ray) is involved in TVU imaging. TVU is a widely accepted procedure used in the evaluation of pelvic abnormalities, allowing for medical evaluation of conditions without the need for invasive surgery or techniques that expose individuals to radiation.

The American Institute of Ultrasound in Medicine (AIUM) in collaboration with the American College of Radiology (ACR), American College of Obstetricians and Gynecologists (ACOG), the Society of Pediatric Radiology (SPR), and the Society of Radiologists in Ultrasound (SRU) published a revised Practice Parameter for the Performance of Ultrasound of the Female Pelvis (AIUM, 2014). This practice parameter provides indications for pelvic ultrasonography, including the transvaginal approach and transabdominal approach. Non-obstetrical indications for TVU include, but are not limited to, evaluation of the following conditions: 1) pelvic pain, pelvic masses, or signs or symptoms of pelvic infection; 2) endocrine abnormalities (including polycystic ovaries); 3) amenorrhea, delayed menses, or dysmenorrhea (painful menses); 4) abnormal vaginal bleeding; 5) congenital uterine and lower genital tract anomalies; 6) postoperative pelvic surgery complications (such as excessive bleeding, pain, or signs of infection); or 7) incontinence or pelvic organ prolapse. Other recommendations for non-obstetrical TVU of the pelvis include: 1) follow-up of a previously detected abnormality; 2) further characterization of a pelvic abnormality noted on another imaging study; 3) guidance for interventional or surgical procedures; 4) localization of an intrauterine contraceptive device; 5) preoperative and postoperative evaluation of pelvic structures; and, 6) screening for malignancy in high-risk individuals.

Screening for Endometrial Cancer with TVU

According to the National Cancer Institute (NCI) PDQ® for endometrial cancer screening (NCI, 2016):

Endometrial cancer is the most common invasive gynecologic cancer in U.S. women, with an estimated 60,050 new cases expected to occur in 2016 and an estimated 10,170 women expected to die of the disease (ACS, 2016). Endometrial cancer is primarily a disease of postmenopausal women with a mean age at diagnosis of 60 years…Since 2005, incidence rates increased by 1.9% per year among women aged 50 years and older. Between 2003 and 2012, death rates for endometrial cancer increased by 1.1% per year (ACS, 2016). Most cases of endometrial cancer are diagnosed because of symptoms, which are nonetheless "early" stage and have high survival rates.

TVU is used as a diagnostic tool to evaluate symptomatic vaginal bleeding by measuring endometrial thickness (ET). In an early systematic review and meta-analysis, Smith-Bindman and colleagues (1998) evaluated 35 studies including 5892 women to determine the accuracy of TVU in detecting endometrial disease in postmenopausal individuals with vaginal bleeding according to hormone replacement use. TVU was found to have a high sensitivity for detecting endometrial cancer and other endometrial disease. Among individuals with postmenopausal uterine bleeding and cancer, 96% (95% confidence interval [CI], 94%-98%) with cancer were found to have an abnormal ET (> 5 millimeters [mm]) on TVU, while 92% (95% CI, 90%-93%) with endometrial disease (that is, cancer, polyp, or atypical hyperplasia) had an abnormal result. In individuals not using hormone replacement therapy, 593 (8%) with normal histological finding had an abnormal TVU result (specificity, 92%; 95% CI, 90%-94%), while 1544 (23%) using hormone replacement therapy had an abnormal TVU result (specificity, 77%; 95% CI, 75%-79%). The probability of cancer in a postmenopausal individual with vaginal bleeding with a 10% pretest probability of endometrial cancer was 1% following a normal TVU result.

Gull and colleagues (2003) used dilation and curettage as a "gold standard" to evaluate TVU measurement of ET as a predictor of endometrial cancer in individuals reporting postmenopausal bleeding (estrogen-progestin therapy [hormone therapy] and no hormone therapy users). A total of 339 participants were evaluated, of which 39 (11.5%) were diagnosed with endometrial cancer (4 participants had an ET of 5-7 mm and 35 participants had an ET > 8 mm) based on histopathology from curettage. No endometrial cancer was diagnosed in individual with a recurrent postmenopausal bleeding who had an ET of less than 4 mm at the initial scan. The authors reported 100% sensitivity and 60% specificity of TVU for diagnosing endometrial cancer when using a cutoff point of 4 mm.

An ACOG practice bulletin on endometrial cancer (2015) includes the following recommendation ("limited or inconsistent scientific evidence: Level B") for use of TVU, stating that "when transvaginal ultrasonography is performed for the initial evaluation of patients with postmenopausal bleeding and an endometrial thickness of less than or equal to 4 mm is found, endometrial sampling is not required." This recommendation is reiterated in the ACOG committee opinion bulletin on endometrial intraepithelial neoplasia (2015), a clinically significant condition that is often a precursor lesion to adenocarcinoma of the endometrium, stating that TVU has excellent negative predictive value (NPV) for endometrial cancer in women with postmenopausal bleeding.

The ACOG practice bulletin on the diagnosis of abnormal uterine bleeding (AUB) in reproductive-aged women (2012), states the primary imaging test of the uterus for the evaluation of AUB is TVU. TVU "is useful as a screening test to assess the endometrial cavity for leiomyomas and polyps." While TVU is helpful for evaluating the myometrium itself, its sensitivity and specific are lower for evaluating intracavitary pathology (56% and 73%, respectively). Regarding use of TVU in evaluation of AUB in premenopausal women, the ACOG practice bulletin (2015) on endometrial cancer states that data is insufficient to support the use of endometrial thickness in the evaluation of AUB in women of reproductive age who are at low risk. "Ultrasound measurement of endometrial thickness in premenopausal women has no diagnostic value and should not be performed."

For use of TVU in individuals without vaginal bleeding, the NCI PDQ for endometrial cancer screening (2016) states that "although TVU can be used to evaluate asymptomatic and occult endometrial pathology, the technique has not been evaluated as a screening method for reducing mortality in asymptomatic women."

The NCI PDQ for endometrial cancer screening (2016) with TVU concludes:

Routine screening of asymptomatic individuals for endometrial cancer has not been evaluated for its impact on endometrial cancer mortality. No studies have evaluated the efficacy of screening with TVU in reducing mortality from endometrial cancer. Although high-risk groups can be identified, the benefit of screening in reducing endometrial cancer mortality in these high-risk groups has not been evaluated. Using the same cutoffs to define an abnormal ET in asymptomatic individuals (Smith-Bindman, 2004) as used in symptomatic individuals (Smith-Bindman, 1998) would result in large numbers of false-positive test results and larger numbers of unnecessary referrals for cytological evaluations. Published recommendations for screening certain groups of individuals at high risk for endometrial cancer are based on opinion regarding presumptive benefit (Burke, 1997).

TVU has been evaluated for use in individuals taking tamoxifen as part of adjuvant therapy for breast cancer and as chemoprevention for women at risk of breast cancer. The effects of tamoxifen may increase the individuals' risk of developing endometrial pathology, including endometrial polyps, endometrial hyperplasia, and endometrial cancer (NCI, 2016). Fung and colleagues (2003) performed a prospective, longitudinal observational study of 304 individuals using tamoxifen over 6 years. Participants underwent annual TVU screening and those with abnormal TVU findings or symptomatic with bleeding underwent endometrial biopsy. A total of 43% of the TVU examinations had associated significant uterine abnormalities identified that required further medical or surgical investigation and treatment. However, most abnormalities (80%) represented benign polyps for which no treatment was needed. A total of 6 cases of primary endometrial cancer were detected, and all cases presented with irregular bleeding. The sensitivity of ultrasound was only 63.3%, with a specificity of 60.4%, and had a low positive predictive value (PPV) for cancer of only 1%. The investigators concluded that routine sequential TVU in asymptomatic women on tamoxifen "…is not useful because of its low specificity and positive predictive value."

The ACOG committee opinion bulletin on tamoxifen and uterine cancer (2014), citing the study by Fung (2003) and two earlier studies, states "in symptomatic women using tamoxifen, screening for endometrial cancer with routine transvaginal ultrasonography, endometrial biopsy, or both has not been shown to be effective."

Screening for Other Endometrial Conditions with TVU

Adenomyosis occurs when endometrial tissue, which normally lines the uterus, exists within and grows into the muscular wall of the uterus. The displaced endometrial tissue thickens, breaks down, and bleeds during each menstrual cycle. An enlarged uterus and painful, heavy menstrual periods can result. Symptoms most often start late in the childbearing years after having children. The cause of adenomyosis remains unknown, but the disease typically disappears after menopause.

Meredith and colleagues (2009) evaluated the accuracy of TVU for diagnosing adenomyosis in individuals undergoing hysterectomy. The presence or absence of adenomyosis was confirmed by histopathologic analysis of hysterectomy specimens. A total of 14 trials with 1895 participants were included in the meta-analysis. The authors reported that TVU predicted adenomyosis with a likelihood ratio of 4.67 (95% CI, 3.13-6.17). The overall prevalence of adenomyosis was 27.9% (95% CI, 25.5-30.3). The probability of adenomyosis with an abnormal TVU was 66.2% (95% CI, 61.6-70.6). The probability of adenomyosis with a normal TVU was 9.1% (95% CI, 7.3-11.1).

Champaneria and colleagues (2010) conducted a systematic review and meta-analysis of individuals with adenomyosis who had a TVU and/or magnetic resonance imaging (MRI) and whose results were compared with a reference standard. A meta-regression was performed to examine how the index tests compared on diagnostic accuracy. A total of 23 articles involving 2312 individuals met the inclusion criteria. TVU had a pooled sensitivity of 72% (95% CI, 65%-79%), specificity of 81% (95% CI, 77%-85%), positive likelihood ratio of 3.7 (95% CI, 2.1-6.4) and negative likelihood ratio of 0.3 (95% CI 0.1-0.5). MRI had a pooled sensitivity of 77% (95% CI, 67%-85%), specificity of 89% (95% CI, 84%-92%), positive likelihood ratio of 6.5 (95% CI, 4.5-9.3), and negative likelihood ratio of 0.2 (95% CI, 0.1-0.4). The results demonstrated that a correct diagnosis was obtained more often with MRI; however, both TVU and MRI showed high levels of accuracy for the non-invasive diagnosis of adenomyosis.

The ACOG practice bulletin on the diagnosis of abnormal uterine bleeding in reproductive-aged women (2012) states that adenomyosis can be diagnosed with TVU, in particular, in an individual with an abnormal physical examination, such as an enlarged or globular uterus on bimanual examination. "Ultrasonographic findings that support a diagnosis of adenomyosis include heterogeneous myometrium, myometrial cysts, asymmetric myometrial thickness, and subendometrial echogenic linear striations."

Screening for Ovarian Cancer with TVU

The NCI PDQ for ovarian, fallopian tube, and primary peritoneal cancer screening (2016) states:

Ovarian carcinoma is the fifth leading cause of cancer death among women in the United States and has the highest mortality rate of all gynecologic cancers. It is estimated that 22,280 new cases of ovarian cancer will be diagnosed in the United States in 2016, and 14,240 women will die of this disease. From 2003 to 2012, incidence rates decreased by 0.9% per year. Mortality rates decreased by 2.0% per year during the same period. The prognosis for survival from ovarian carcinoma largely depends on stage, which is strongly associated with histopathologic type. Approximately 75% of women with ovarian carcinoma have high-grade serous carcinoma, of which 90% present with stage III or IV disease, leading to poor survival. Ovarian cancer is rare; the lifetime risk of being diagnosed with ovarian cancer is 1.31%.

There is substantive evidence in the peer-reviewed literature in population-based studies to indicate that routine screening of women at average risk of developing ovarian cancer with annual TVU screening does not result in a decrease in ovarian cancer mortality (NCI, 2016). In a randomized controlled clinical trial of individuals recruited from 13 centers across the United Kingdom from 2001 to 2005 (Ovarian Cancer Screening and Mortality in the UK Collaborative Trial of Ovarian Cancer Screening [UKCTOCS] [NCT00058032]), outcomes among 50,623 postmenopausal individuals aged 50 to 74 years who were randomly assigned to 7 to 11 rounds of annual screening with TVU alone and 50,264 who underwent multimodal screening with cancer antigen (CA)-125 testing and TVU were compared with results of 101,299 individuals who were not screened (the comparison group). After trial initiation, but before the final analysis, the protocol was amended twice: 1) the study was extended to achieve greater power, and 2) criteria for referral in the multimodal arm were liberalized to increase the percentage of positive screens (Jacobs, 2016). TVUs were scored as normal, resulting in continued annual screening; intermediate, leading to repeat CA-125 and TVU at 3 months; or abnormal, requiring repeat testing within 6 weeks. In the TVU arm, 314 cancers were diagnosed and 154 ovarian cancer-related deaths occurred compared with the nonscreened arm, in which 630 cancers were diagnosed and 347 ovarian cancer-related deaths occurred. Mortality was nonsignificantly lower with TVU screening (11%; 95% CI, -7% to 27%; p=0.21). TVU screening resulted in 50 surgeries per 10,000 women for a false-positive screen. Complications resulted from less than 1% of screens and 3.4% of operations. Over a median of 11.1 years, ovarian cancer deaths occurred among 0.30% of screened women and 0.34% of unscreened women (Jacobs, 2016; Sharma, 2012). The ovarian cancer mortality rate was 3.8 deaths per 10,000 women in the screened group and 3.6 deaths per 10,000 person-years in the usual-care group, yielding a mortality rate ratio of 1.06 (95% CI, 0.87-1.30) (NCI, 2016).

Buys and colleagues (2011) evaluated the effect of screening for ovarian cancer on mortality in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. This clinical trial conducted at 10 screening centers across the United States randomly assigned 78,216 women aged 55 to 74 years to undergo either annual screening (n=39,105) or usual care (n=39,111). The intervention group was offered annual screening with CA-125 for 6 years and TVU for 4 years. Participants and their health care practitioners received the screening test results and managed evaluation of abnormal results. The usual care group was not offered annual screening with CA-125 for 6 years or TVU but received their usual medical care. Participants were followed up for a maximum of 13 years (median [range], 12.4 years [10.9-13.0 years]) for cancer diagnoses and death until February 28, 2010. The primary outcome was mortality from ovarian cancer, including primary peritoneal and fallopian tube cancers. Secondary outcomes included ovarian cancer incidence and complications associated with screening examinations and diagnostic procedures. A total of 212 women were diagnosed with ovarian cancer (5.7 per 10,000 person-years) in the intervention group and 176 (4.7 per 10,000 person-years) in the usual care group (rate ratio [RR], 1.21; 95% CI, 0.99-1.48). There were 118 deaths as a result of ovarian cancer (3.1 per 10,000 person-years) in the intervention group and 100 deaths (2.6 per 10,000 person-years) in the usual care group (mortality RR, 1.18; 95% CI, 0.82-1.71). Of 3285 women with false-positive results (approximately 10%), 1080 underwent surgical follow-up; 163 women experienced at least one serious complication (15%). A total of 2924 deaths were attributed to other causes (excluding ovarian, colorectal, and lung cancer) (76.6 per 10,000 person-years) in the intervention group and 2914 deaths (76.2 per 10,000 person-years) in the usual care group (RR, 1.01; 95% CI, 0.96-1.06). The results of this large population-based clinical trial among women in the general U.S. population concluded that simultaneous screening with CA-125 and TVU compared with usual care did not reduce ovarian cancer mortality. The PPV of CA-125 and TVU screening was just greater than 1% across all screening rounds. In addition, diagnostic evaluation following a false-positive screening test result was associated with complications (Buys, 2011; Partridge, 2009).

The current U.S. Preventive Services Task Force (USPSTF) guidelines for ovarian cancer screening among asymptomatic, average-risk women (Moyer, 2012) recommend against screening for ovarian cancer in women, as "there is moderate or high certainty that the service has no net benefit or that harms outweigh the benefits (Grade D: The USPSTF recommends against the service)." This reaffirmation statement indicates the USPSTF found adequate evidence that annual screening with TVU and testing for a serum tumor marker CA-125 in women does not reduce the number of ovarian cancer deaths (Danforth, 2012). This recommendation applies to asymptomatic women; however, women with known genetic mutations that increase their risk for ovarian cancer (for example, BRCA mutations) are not included in this recommendation.

The ACOG Committee on Gynecologic Practice and Society of Gynecologic Oncologists published a committee opinion on the role of the obstetrician-gynecologist in the early detection of epithelial ovarian cancer (2011), stating the use of TVU as a potential screening strategy in low risk, asymptomatic women has proved ineffective because the sensitivity, specificity, PPV, and NPV all have been "modest at best." However, ACOG concludes that:

TVU in Individuals with Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome and Peutz-Jeghers Syndrome

Hereditary Breast and Ovarian Cancer Syndrome

According to the NCCN CPG for genetic/familial high-risk assessment in breast and/or ovarian cancer (NCCN, V2.2017), "specific patterns of hereditary breast/ovarian cancers are linked to mutations in the BRCA 1/2 genes." It is generally accepted that carriers of mutations of BRCA 1/2 genes "have an excessive risk for both breast and ovarian cancer that warrants consideration of more intensive screening and preventive strategies." In the clinical management of individuals with a confirmed BRCA 1/2 mutation (or highly suspected of having the mutation based on presence of known deleterious mutation in the family), post-test counseling should include discussion of risk-reducing mastectomy and/or salpingo-oophorectomy. The CPG recommends:

…risk-reducing salpingo-oophorectomy (RRSO), typically between 35 and 40 years, and upon completion of child bearing. Because ovarian cancer onset in patients with BRCA 2 mutations is an average of 8-10 years later than in patients with BRCA 1 mutations, it is reasonable to delay RRSO until age 40-45 years in patients with BRCA 2 mutations who have already maximized their breast cancer prevention (ie, undergone bilateral mastectomy).

For management of BRCA mutation-positive individuals who have not elected RRSO, the NCCN CPG (V2.2017) states that screening with "…transvaginal ultrasound for ovarian cancer has not been shown to be sufficiently sensitive or specific as to support a positive recommendation, but may be considered at the clinician's discretion starting at age 30-35 years." This category 2A recommendation (based upon lower-level evidence, there is uniform NCCN consensus that the intervention is appropriate) considers screening guidelines reported in a systematic review (Lindor, 2006) and outcomes of the UKCTOCS clinical trial (Jacobs, 2016; Menon, 2009).

The National Society of Genetic Counselors (NSGC) has published a practice guideline on risk assessment and genetic counseling for hereditary breast and ovarian cancer (Berliner, 2013). Medical management (surveillance) options for high-risk women are as follows:

Although unproven, annual or semiannual transvaginal ultrasound, pelvic exam and testing for serum CA-125 to screen for ovarian cancer beginning at 30 years of age should be considered.

The ACOG practice bulletin on hereditary breast and ovarian cancer syndrome (2009) recommends that RRSO, including removal of the ovaries and fallopian tubes in their entirety, be offered by age 40 years for women with BRCA 1 or BRCA 2 mutations. In addition, the practice bulletin states:

Current strategies to reduce the risk of developing ovarian cancer or fallopian tube cancer in women at high risk with known deleterious BRCA mutations include surveillance, chemoprevention, and surgery. Available screening procedures have a limited ability to detect ovarian cancer at an early, more curable stage of disease, and patients should be informed that there is no evidence that screening has reduced the mortality or improved the survival associated with ovarian cancer in high-risk populations. Nevertheless, given the extremely high risk for ovarian cancer and fallopian tube cancer in women with mutations in BRCA 1 or BRCA 2, consensus groups have recommended periodic screening with CA 125 and transvaginal ultrasonography, beginning between the ages of 30 years and 35 years or 5-10 years earlier than the earliest age of first diagnosis of ovarian cancer in the family (Burke, 1997).

Lynch Syndrome

Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is a rare genetic (autosomal dominant) inherited cancer susceptibility syndrome that increases the risk of many types of cancer, particularly, cancers of the colon (large intestine) and rectum, collectively referred to as colorectal cancer, and cancers of the endometrium, ovaries, stomach, small intestine, liver, gallbladder duct, upper urinary tract, and brain. Women with Lynch syndrome are at increased risk for endometrial and ovarian cancers; however, estimates of the cumulative lifetime risk of ovarian cancer in individuals with Lynch syndrome ranges from 3.4% to 22%. In addition, the National Comprehensive Cancer Network® (NCCN® ) Clinical Practice Guidelines (CPGs) in Oncology® for the management of individuals with a genetic/familial high-risk for colorectal cancer (NCCN, V2.2016) states:

Identification of Lynch syndrome is important both for individuals with cancer, because of high personal risk of metachronous Lynch syndrome cancers (that is, endometrial cancer after colorectal cancer or vice versa; second colorectal cancer), and for their families because of autosomal dominant inheritance and potentially high penetrance. After identification of Lynch syndrome, surveillance (particularly for first or metachronous CRC) offers an opportunity for early detection and perhaps even prevention of cancer among mutation carriers.

Two early studies evaluating TVU and measurement of the endometrial lining for endometrial cancer surveillance in a population of women at high-risk of HNPCC and familial colorectal cancer reported that TVU screening had a high false-positive rate and lacked efficacy (Dove-Edwin, 2002; Rijcken, 2003).

Lindor and colleagues (2006) performed a systematic review of the literature on cancer risks and data on screening efficacy for Lynch syndrome with the intent to provide recommendations for clinical management for affected families. While the authors acknowledged the absence of demonstrated efficacy, the current gynecologic cancer screening guidelines for women with Lynch syndrome should include annual endometrial sampling and TVU beginning at age 30 to 35 years.

Lécuru (2010) and colleagues assessed the performance of TVU to screen for atypical hyperplasia and endometrial cancer in women at risk for Lynch syndrome. Endometrial biopsy was the reference standard. Of 85 women with mismatch repair gene mutations or Amsterdam II criteria, 58 had 96 paired ultrasound-biopsy evaluations and were included in the study. TVU or transabdominal ultrasonographic finding was considered normal if no polyps or intrauterine abnormalities were seen and if the maximum endometrial thickness was less than 4 mm in postmenopausal women not receiving hormonal replacement therapy or less than 6 mm in other women. Endometrial biopsy results were categorized as not interpretable, normal, or showing atypical hyperplasia or cancer. Sensitivity, specificity, PPV, NPV, and likelihood ratio of ultrasonography were computed. The median follow-up duration was 51.4 months, with cancer diagnosed in 2 individuals. TVU had 100% sensitivity and 100% NPV, 2.2 positive likelihood ratio, and 0 negative likelihood ratio. No interval cancers occurred.

The ACOG practice bulletin on the clinical management of Lynch syndrome (2014) states there is no consensus on ovarian cancer surveillance in women with Lynch syndrome. Citing results from the largest gynecologic cancer surveillance study to date (Renkonen-Sinisalo, 2007), neither TVU nor CA-125 testing led to the diagnosis of ovarian cancer in any of the 175 Lynch syndrome mutation carriers screened; therefore, it is unclear whether screening with TVU is effective in women with Lynch syndrome.

More recently, the NCCN CPGs address the use of TVU in the assessment and management of individuals with a genetic/familial high-risk for colorectal cancer (NCCN, V2.2016) and a genetic/familial high-risk for breast and/or ovarian cancer (NCCN, V2.2017). Both NCCN CPGs (V2.2016; V2.2017) state for women with Lynch syndrome who have completed childbearing and carry a MLH 1, MSH 2, EPCAM , PMS 2, or MSHS gene mutation, total abdominal hysterectomy and/or bilateral salpingo-oophorectomy are options that may be considered for risk reduction; however, "there is no clear evidence to support routine screening for gynecologic cancers in these mutation carriers," and no recommendation for use of TVU for screening or surveillance for colorectal cancer.

The American College of Gastroenterology (ACG) (Syngal, 2015) has published guidelines for the surveillance and management of individuals with hereditary gastrointestinal cancer syndromes, including those addressing the surveillance and management of extracolonic malignancies. For individuals with Lynch syndrome, the recommendations state:

Screening for endometrial cancer (EC) and ovarian cancer should be offered to women at risk for or affected with Lynch syndrome (LS) by endometrial biopsy and transvaginal ultrasound annually, starting at age 30 to 35 years before undergoing surgery or if surgery is deferred (conditional recommendations, very low quality of evidence).

Peutz-Jeghers Syndrome

Peutz-Jeghers syndrome is a rare autosomal dominant condition characterized by the development of noncancerous growths called hamartomatous polyps in the gastrointestinal tract (particularly the stomach and intestines). Most people with Peutz-Jeghers syndrome develop multiple polyps in the stomach and intestines during childhood or adolescence. Polyps can cause health problems such as recurrent bowel obstructions, chronic bleeding, and abdominal pain. Individuals with Peutz-Jeghers syndrome have an increased risk of developing certain types of cancers (such as, colorectal, pancreas, cervix, ovary, gallbladder, or breast cancer) during their lifetime.

The ACG clinical guideline on genetic testing and management of hereditary gastrointestinal cancer syndromes (Syngal, 2015) states in affected or at-risk individuals with Peutz-Jeghers syndrome, surveillance should include monitoring for colon, stomach, small bowel, pancreas, breast, ovary, uterus, cervix, and testes cancers. Pelvic exam and pelvic ultrasound or TVU are recommended surveillance procedures for endometrial cancer beginning around 25 years of age (conditional recommendation). For ovarian cancer surveillance, "pelvic exam and pelvic or transvaginal ultraound, CA-125 are probably not helpful." No peer-reviewed publications are cited with this recommendation.

The NCCN CPG for genetic/familial high-risk assessment for colorectal cancer (NCCN, V2.2016) includes cancer risk and surveillance guidelines for the management of Peutz-Jeghers syndrome, including screening of the ovaries, cervix, and uterus beginning at "approximately 18-20 years" of age. The category 2A recommendation is based on the following:

As there are limited data regarding the efficacy of various screening modalities in Peutz-Jeghers syndrome (PJS), panel recommendations were made while taking into consideration cancer risk in PJS and the known utility of specific screening modalities. To monitor for gynecologic cancer…transvaginal ultrasound may also be considered.

TVU for Adnexal, Pelvic and Other Gynecologic-Related Conditions

Adnexal masses (that is, masses of the ovary, fallopian tube, or surrounding tissues) may be detected incidentally on physical examination or at the time of pelvic imaging. Less commonly, a mass may present with symptoms of acute or intermittent pain. TVU has been used with or without other imaging modalities including transrectal ultrasonography (TRUS) and TRUS-guided transrectal biopsy to: 1) evaluate the extension of adnexal and pelvic masses, including masses of the cervix, fallopian tube, ovary, retroperitoneum, uterus, or surrounding tissues; and, 2) guide or manage further treatment (such as drainage of deep pelvic and perirectal abscesses) (Giede, 2004; Lorentzen, 2011; Nielsen, 2004; Valentin, 2013a; Valentin, 2013b; Zaritzky, 1979).

The ACOG practice bulletin on the evaluation and management of adnexal masses (2016) states "although most adnexal masses are benign, the main goal of the diagnostic evaluation is to exclude malignancy." Based on "good and consistent scientific evidence (Level A)," ACOG provides the following recommendations and conclusions:

Based on "limited or inconsistent scientific evidence (Level B)," the ACOG practice bulletin (2016) recommends:

TVU for the Evaluation and Management of Endometriosis

According to the ACOG practice bulletin for management of endometriosis (2010), the condition is a gynecologic disorder whose principal symptoms are chronic pain and infertility. The condition occurs in 6% to 10% of women of reproductive age with a greater prevalence in infertile women and women with chronic pelvic pain (38% and 71%-87%, respectively). Clinical manifestations of endometriosis are unpredictable and variable in both presentation and course, and include dysmenorrhea, chronic pelvic pain, dyspareunia, utero-sacral ligament nodularity, and either a symptomatic or asymptomatic adnexal mass.

Guerriero and colleagues (2015) performed a systematic review and meta-analysis to determine the diagnostic accuracy of TVU in the preoperative detection of endometriosis in the uterosacral ligaments (USL), rectovaginal septum (RVS), and the vagina and bladder in individuals with clinical suspicion of deep infiltrating endometriosis (DIE). A total of 11 studies (n=1583) were included in the meta-analysis including those by Bazot (2014), Bazot (2009), and Hudelist (2011a). For detection of endometriosis in the USL, the overall pooled sensitivity and specificity of TVU were 53% (95% CI, 35%-70%) and 93% (95% CI, 83%-97%), respectively. The pretest probability of USL endometriosis was 54%, which increased to 90% when suspicion of endometriosis was present after TVU examination. The overall pooled sensitivity and specificity were 49% (95% CI, 36%-62%) and 98% (95% CI, 95%-99%), respectively for detection of endometriosis in the RVS. The pretest probability of RVS endometriosis was 24%, which increased to 89% when suspicion of endometriosis was present after TVU examination. For detection of vaginal endometriosis, the overall pooled sensitivity and specificity were 58% (95% CI, 40%-74%) and 96% (95% CI, 87%-99%), respectively. The pretest probability of vaginal endometriosis was 17%, which increased to 76% when suspicion of endometriosis was present after TVU assessment. The overall pooled sensitivity and specificity were 62% (95% CI, 40%-80%) and 100% (95% CI, 97%-100%), respectively for the detection of bladder endometriosis. The pretest probability of bladder endometriosis was 5%, which increased to 92% when suspicion of endometriosis was present after TVU assessment. The authors concluded that the overall diagnostic performance of TVU for detecting DIE in USL, RVS, and the vagina and bladder "is fair with high specificity."

The following ACOG clinical guideline recommendation in the management of endometriosis (2010) is based on "good and consistent scientific evidence (Level A)," stating that "imaging studies alone appear to have high predictive accuracy in differentiating an ovarian endometrioma from other adnexal masses, and transvaginal ultrasonography is the imaging modality of choice when assessing the presence of endometriosis." In addition, TUV "is also the imaging technique of choice to detect the presence of deeply infiltrating endometriosis of the rectum or rectovaginal septum."

TVU for Confirmation of an Intrauterine Device (IUD)

De Kroon and colleagues (2003) conducted a prospective study comparing clinical evaluation with TVU measurement of intrauterine device position both immediately after insertion and 6 weeks after insertion. The primary outcome measures were the PPV and NPV of the clinical evaluation of the IUD position. A total of 195 consecutive women were implanted with an IUD, of which 181 (92.8%) were available for follow-up. Immediately after insertion, the PPV and NPV of clinical evaluation of IUD position were 0.60 (95% CI, 0.39-0.81) and 0.98 (95% CI, 0.96-1.0), respectively. The prevalence of an abnormally position IUD was 7.7% (95% CI, 3.9-11.4). The PPV and NPV of clinical evaluation at follow-up were 0.54 (95% CI, 0.26-0.81) and 1.0 (95% CI, 0.98 to 1.0), respectively. The prevalence of abnormal position was 4.0% (95% CI, 1.7 to7.1). The investigators concluded that the routine use of TVU to monitor the position of an IUD is not indicated as the results of this study show that "without clinical suspicion of an erroneous position, the chances of an inadequately positioned IUD are negligible."

The ACOG committee opinion bulletin on clinical challenges of long-acting reversible contraceptive methods (2016) states that when IUD strings are not visualized, correct location should be confirmed before the IUD can be relied on for contraception. In these situations where the string is no longer visible, TVU is a viable modality to confirm or reject that the IUD is correctly located in the endometrial cavity.  


Transvaginal: Through the vagina.


Peer Reviewed Publications:

  1. Archer DF, McIntyre-Seltman K, Wilborn WW Jr, et al. Endometrial morphology in asymptomatic postmenopausal women. Am J Obstet Gynecol. 1991; 165(2):317-320.
  2. Bazot M, Malzy P, Cortez A, et al. Accuracy of transvaginal sonography and rectal endoscopic sonography in the diagnosis of deep infiltrating endometriosis. Ultrasound Obstet Gynecol. 2007; 30(7):994-1001.
  3. Bazot M, Thomassin I, Hourani R, et al. Diagnostic accuracy of transvaginal sonography for deep pelvic endometriosis. Ultrasound Obstet Gynecol. 2004; 24(2):180-185.
  4. Buys SS, Partridge E, Black A, et al. Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA. 2011; 305(22):2295-2303.
  5. Champaneria R, Abedin P, Daniels J, et al. Ultrasound scan and magnetic resonance imaging for the diagnosis of adenomyosis: systematic review comparing test accuracy. Acta Obstet Gynecol Scand. 2010; 89(11):1374-1384.
  6. de Kroon CD, van Houwelingen JC, Trimbos JB, Jansen FW. The value of transvaginal ultrasound to monitor the position of an intrauterine device after insertion. A technology assessment study. Hum Reprod. 2003; 18(11):2323-2327.
  7. Dove-Edwin I, Boks D, Goff S, et al. The outcome of endometrial carcinoma surveillance by ultrasound scan in women at risk of hereditary non-polyposis colorectal carcinoma and familial colorectal carcinoma. Cancer. 2002; 94(6):1708-1712.
  8. Egekvist AG, Forman A, Seyer-Hansen M. Transvaginal ultrasonography of rectosigmoid endometriosis: interobserver variation of lesion size. Acta Obstet Gynecol Scand. 2012; 91(2):264-268.
  9. Farquhar C, Ekeroma A, Furness S, Arroll B. A systematic review of transvaginal ultrasonography, sonohysterography and hysteroscopy for the investigation of abnormal uterine bleeding in premenopausal women. Acta Obstet Gynecol Scand. 2003; 82(6):493-504.
  10. Fleischer AC, Wheeler JE, Lindsay I, et al. An assessment of the value of ultrasonographic screening for endometrial disease in postmenopausal women without symptoms. Am J Obstet Gynecol. 2001; 184(2):70-75.
  11. Fung MF, Reid A, Faught W, et al. Prospective longitudinal study of ultrasound screening for endometrial abnormalities in women with breast cancer receiving tamoxifen. Gynecol Oncol. 2003; 91(1):154-159.
  12. Giede C, Toi A, Chapman W, Rosen B. The use of transrectal ultrasound to biopsy pelvic masses in women. Gynecol Oncol. 2004; 95(3):552-556.
  13. Goff BA, Mandel LS, Melancon CH, Muntz HG. Frequency of symptoms of ovarian cancer in women presenting to primary care clinics. JAMA. 2004; 291(22):2705-2712.
  14. Guerriero S, Ajossa S, Minguez JA, et al. Accuracy of transvaginal ultrasound for diagnosis of deep endometriosis in uterosacral ligaments, rectovaginal septum, vagina and bladder: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2015; 46(5):534-545.
  15. Gull B, Karlsson B, Milsom I, Granberg S. Can ultrasound replace dilation and curettage? A longitudinal evaluation of postmenopausal bleeding and transvaginal sonographic measurement of the endometrium as predictors of endometrial cancer. Am J Obstet Gynecol. 2003; 188(2):401-408.
  16. Hudelist G, Ballard K, English J, et al. Transvaginal sonography vs. clinical examination in the preoperative diagnosis of deep infiltrating endometriosis. Ultrasound Obstet Gynecol. 2011a; 37(4):480-487.
  17. Hudelist G, English J, Thomas AE, et al. Diagnostic accuracy of transvaginal ultrasound for non-invasive diagnosis of bowel endometriosis: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2011b; 37(3):257-263.
  18. Jacobs IJ, Menon U, Ryan A, et al. Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet. 2016; 387(10022):945-956.
  19. Kobayashi H, Yamada Y, Sado T, et al. A randomized study of screening for ovarian cancer: a multicenter study in Japan. Int J Gynecol Cancer. 2008; 18(3):414-420.
  20. Langer RD, Pierce JJ, O'Hanlan KA, et al. Transvaginal ultrasonography compared with endometrial biopsy for the detection of endometrial disease. Postmenopausal Estrogen/Progestin Interventions Trial. N Engl J Med. 1997; 337(25):1792-1798.
  21. Lécuru F, Huchon C, Metzger U, et al. Contribution of ultrasonography to endometrial cancer screening in patients with hereditary nonpolyposis colorectal cancer/Lynch syndrome. Int J Gynecol Cancer. 2010; 20(4):583-587.
  22. Lindor NM, Petersen GM, Hadley DW, et al. Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review. JAMA. 2006; 296(12):1507-1517.
  23. Lorentzen T, Nolsøe C, Skjoldbye B. Ultrasound-guided drainage of deep pelvic abscesses: experience with 33 cases. Ultrasound Med Biol. 2011; 37(5):723-728.
  24. Menon U, Gentry-Maharaj A, Hallett R, et al. Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Lancet Oncol. 2009; 10(4):327-340.
  25. Meredith SM, Sanchez-Ramos L, Kaunitz AM. Diagnostic accuracy of transvaginal sonography for the diagnosis of adenomyosis: systematic review and metaanalysis. Am J Obstet Gynecol. 2009; 201(1):e101-e106.
  26. Modesitt SC, Pavlik EJ, Ueland FR, et al. Risk of malignancy in unilocular ovarian cystic tumors less than 10 centimeters in diameter. Obstet Gynecol. 2003; 102(3):594-599.
  27. Naftalin J, Hoo W, Pateman K, et al. How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum Reprod. 2012; 27(12):3432-3439.
  28. Nielsen MB, Torp-Pedersen S. Sonographically guided transrectal or transvaginal one-step catheter placement in deep pelvic and perirectal abscesses. AJR Am J Roentgenol. 2004; 183(4):1035-1036.
  29. Ozdemir S, Celik C, Gezginc K, et al. Evaluation of endometrial thickness with transvaginal ultrasonography and histopathology in premenopausal women with abnormal vaginal bleeding. Arch Gynecol Obstet. 2010; 282(4):395-399.
  30. Partridge E, Kreimer AR, Greenlee RT, et al.; PLCO Project Team. Results from four rounds of ovarian cancer screening in a randomized trial. Obstet Gynecol. 2009; 113(4):775-782.
  31. Renkonen-Sinisalo L, Bützow R, Leminen A, et al. Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome. Int J Cancer. 2007; 120(4):821-824.
  32. Rijcken FE, Mourits MJ, Kleibeuker JH, et al. Gynecologic screening in hereditary nonpolyposis colorectal cancer. Gynecol Oncol. 2003; 91(1):74-80.
  33. Savelli L, Manuzzi L, Coe M, et al. Comparison of transvaginal sonography and double-contrast barium enema for diagnosing deep infiltrating endometriosis of the posterior compartment. Ultrasound Obstet Gynecol. 2011; 38(4):466-471.
  34. Sharma A, Apostolidou S, Burnell M, et al. Risk of epithelial ovarian cancer in asymptomatic women with ultrasound-detected ovarian masses: a prospective cohort study within the UK collaborative trial of ovarian cancer screening (UKCTOCS). Ultrasound Obstet Gynecol. 2012; 40(3):338-344.
  35. Sharma A, Gentry-Maharaj A, Burnell M, et al. Assessing the malignant potential of ovarian inclusion cysts in postmenopausal women within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a prospective cohort study. BJOG. 2012; 119(2):207-219.
  36. Smith-Bindman R, Kerlikowske K, Feldstein VA, et al. Endovaginal ultrasound to exclude endometrial cancer and other  endometrial abnormalities. JAMA. 1998; 280(17):1510-1517.
  37. Smith-Bindman R, Weiss E, Feldstein V. How thick is too thick? When endometrial thickness should prompt biopsy in postmenopausal women without vaginal bleeding. Ultrasound Obstet Gynecol. 2004; 24(5):558-565.
  38. Valentin L, Ameye L, Franchi D, et al. Risk of malignancy in unilocular cysts: a study of 1148 adnexal masses classified as unilocular cysts at transvaginal ultrasound and review of the literature. Ultrasound Obstet Gynecol. 2013a; 41(1):80-89.
  39. Valentin L, Ameye L, Savelli L, et al. Unilocular adnexal cysts with papillary projections but no other solid components: is there a diagnostic method that can classify them reliably as benign or malignant before surgery? Ultrasound Obstet Gynecol. 2013b; 41(5):570-581.
  40. van Nagell JR Jr, DePriest PD, Ueland FR, et al. Ovarian cancer screening with annual transvaginal sonography: findings of 25,000 women screened. Cancer. 2007; 109(9):1887-1896.

Government Agency, Medical Society, and Other Authoritative Publications:

  1. American College of Obstetricians and Gynecologists (ACOG). Committee on Gynecologic Practice. Committee Opinions. Available at: Accessed on December 12, 2016.
    • Committee Opinion Number 440. The role of transvaginal ultrasonography in the evaluation of postmenopausal bleeding. August 2009. Reaffirmed 2015.
    • Committee Opinion Number 477. The role of the obstetrician-gynecologist in the early detection of epithelial ovarian cancer. March 2011.
    • Committee Opinion Number 601. Tamoxifen and uterine cancer. June 2014.
    • Committee Opinion Number 672. Clinical challenges of long-acting reversible contraceptive methods. September 2016.
    • Committee Opinion Number 631. Endometrial intraepithelial neoplasia. May 2015.
  2. American College of Obstetricians and Gynecologists; ACOG Committee on Practice Bulletins-Gynecology; ACOG Committee on Genetics; Society of Gynecologic Oncologists. ACOG Practice Bulletin No. 103: Hereditary breast and ovarian cancer syndrome. Obstet Gynecol. 2009; 113(4):957-966.
  3. American College of Obstetricians and Gynecologists (ACOG). Practice Bulletin No. 114: Management of endometriosis. Obstet Gynecol. 2010; 116(1):223-236.
  4. American College of Obstetricians and Gynecologists (ACOG). Practice Bulletin No. 128: Diagnosis of abnormal uterine bleeding in reproductive-aged women. Obstet Gynecol. 2012; 120(1):197-206.
  5. American College of Obstetricians and Gynecologists (ACOG). Practice Bulletin No. 174: Evaluation and management of adnexal masses. Obstet Gynecol. 2016; 128(5):e210-e226.
  6. American College of Obstetricians and Gynecologists (ACOG). Society of Gynecologic Oncology (SCO). ACOG Practice Bulletin No. 147: Lynch syndrome. Obstet Gynecol. 2014; 124(5):1042-1054.
  7. American College of Obstetricians and Gynecologists (ACOG). Society of Gynecologic Oncology (SCO). Practice Bulletin No. 149: Endometrial cancer. Obstet Gynecol. 2015; 125(4):1006-1026.
  8. American College of Radiology (ACR). ACR® Appropriateness Criteria. Diagnostic: Women. Topic Names. Available at: . Accessed on December 12, 2016.
  9. American Institute of Ultrasound in Medicine (AIUM); American College of Radiology (ACR); American College of Obstetricians and Gynecologists (ACOG); Society for Pediatric Radiology (SPR); Society of Radiologists in Ultrasound (SRU). AIUM practice guideline for the performance of ultrasound of the female pelvis. J Ultrasound Med. 2014; 33(6):1122-1130.
  10. Berliner JL, Fay AM, Cummings SA, et al. NSGC practice guideline: risk assessment and genetic counseling for hereditary breast and ovarian cancer. J Genet Couns. 2013; 22(2):155-163.
  11. Burke W, Daly M, Garber J, et al. Recommendations for follow-up care of individuals with an inherited predisposition to cancer. II. BRCA1 and BRCA2. Cancer Genetics Studies Consortium. JAMA. 1997; 277(12):997-1003.
  12. Daly MB, Pilarski R, Berry M, et al. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2017. J Natl Compr Canc Netw. 2017; 15(1):9-20.
  13. Danforth KN, Im TM, Whitlock EP. Addendum to Screening for Ovarian Cancer: Evidence Update for the U.S. Preventive Services Task Force Reaffirmation Recommendation Statement. AHRQ Publication No. 12-05165-EF4. Rockville, MD: Agency for Healthcare Research and Quality; April 2012. Available at: . Accessed on December 12, 2016.
  14. Moyer VA; U.S. Preventive Services Task Force. Screening for ovarian cancer: U.S. Preventive Services Task Force reaffirmation recommendation statement. Ann Intern Med. 2012; 157(12):900-904.
  15. NCCN Clinical Practice Guidelines in Oncology® . © 2016 National Comprehensive Cancer Network, Inc. For additional information visit the NCCN website: Accessed on December 12, 2016.
    • Genetic/Familial High-Risk Assessment: Breast and Ovarian (V2.2017). Revised December 7, 2016.
    • Genetic/Familial High-Risk Assessment: Colorectal (V2.2016). Revised September 26, 2016.
  16. Syngal S, Brand RE, Church JM, et al; American College of Gastroenterology. ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol. 2015; 110(2):223-262.
Websites for Additional Information
  1. American Cancer Society (ACS). Cancer Facts and Figures 2016. Available at: Accessed on December 12, 2016.
  2. National Cancer Institute (NCI). Available at: Accessed on December 12, 2016.
    • Endometrial Cancer Screening (PDQ® ). Updated March 4, 2016.
    • Ovarian, Fallopian Tube, and Primary Peritoneal Cancer Screening (PDQ® ). Updated November 18, 2016.

Transvaginal ultrasound

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New 02/02/2017 Medical Policy & Technology Assessment Committee (MPTAC) review. Initial document development.