Medical Policy


Subject: Quantitative Sensory Testing
Document #: MED.00082 Publish Date:    12/27/2017
Status: Reviewed Last Review Date:    11/02/2017


This document addresses quantitative sensory testing (QST) used for the noninvasive evaluation of sensory nerve function in individuals with symptoms of, or the potential for, neurologic damage or disease. QST systems can assess and quantify the amount of physical stimuli required for sensory perception to occur. Various testing modalities used in QST can evaluate the sensory nerves involved in touch, pressure, pain, thermal (warm and cold), and vibration.

This document highlights two QST methods: threshold testing, also known as current perception sensory nerve conduction threshold testing, and pressure-specified sensory device testing.

Position Statement

Investigational and Not Medically Necessary:

Quantitative sensory testing including, but not limited to current perception threshold testing, also known as sensory nerve conduction threshold testing, and pressure-specified sensory device testing is considered investigational and not medically necessary. 


Quantitative Sensory Testing

QST can be used either as an initial diagnostic test or as a monitoring test in individuals with sensory deficits. QST has been proposed as an alternative to nerve conduction but QST is able to evaluate large, small and unmyelinated nerve fibers, whereas nerve conduction studies are limited to large fiber nerves. When used as a monitoring technique, test/retest reliability is an important factor, as well as defining clinically significant change in sensory perception as QST is a psychophysiological test much like audiography and ophthalmological refraction and reference standards have been difficult to establish.

In a 2003 report, the American Academy of Neurology (AAN) (re-affirmed in 2005, 2008 and 2013) noted QST should not be used as a sole method for diagnosis of pathology. The AAN indicated QST poses technical challenges in the methodology of testing, reproducibility, and psychophysical factors that limit the objectivity of testing results. In a review, Siao and Cros (2003) also noted QST is influenced by many extraneous factors and may be subject to misinterpretation and misuse. In addition, normal reference values vary between various methodologies, and reproducibility of QST has not been firmly established as there is significant variability between the different methodologies regarding testing techniques and interpretation of results.

In a technology literature review of QST, the American Association of Electrodiagnostic Medicine (AAEM) (Chong, 2004) concluded, the “Literature data do not allow a conclusion regarding the relative merits of individual QST instruments.”

An updated literature search based on the MEDLINE database through September 2017 did not identify any new articles that would resolve the use of diagnostic quantitative sensory testing (QST) used for the noninvasive evaluation of sensory nerve function in individuals with symptoms or the potential for neurologic damage or disease.

Sensory Nerve Conduction Threshold Testing

Sensory nerve conduction threshold testing has been investigated for a broad range of clinical applications, including evaluation of peripheral neuropathies, detection of carpal tunnel syndrome, spinal radiculopathy, evaluation of the effectiveness of peripheral nerve blocks, quantification of hypoesthetic and hyperesthetic conditions and differentiation of psychogenic from neurologic disorders.

Freeman and colleagues (2003) conducted a case series to determine the differentiation between QST results for small and large fiber sensory loss between individuals with peripheral neuropathy (PN), normal controls and a group of normal subjects who were asked to attempt simulating sensory loss during the testing. The subjects were tested for cold and vibration perception levels with the CASE IV sensory testing system. There were no differences between performance characteristics in the two simulation trials. Responses to null stimuli did not differentiate between groups. Freeman and colleagues concluded, “Test performance characteristics do not permit discrimination among subjects simulating sensory loss, subjects with normal responses, and subjects with peripheral neuropathy.”

In 1999, the American Association of Electrodiagnostic Medicine (AAEM) published a technology review of the Neurometer® device (Neurotron, Inc., Baltimore, MD). This device uses electrical currents of three different frequencies to activate sensory axons in the unmyelinated, small myelinated and large myelinated fiber populations. The methodology is termed Current Perception Threshold testing (CPT). This review suggested the following criteria for the evaluation of the device:

The AAEM assessment concluded there was inadequate scientific literature meeting the above criteria to validate the clinical role of current perception threshold testing.

In 2003, the Centers for Medicaid and Medicare Services (CMS) issued a decision memorandum in support of a national noncoverage determination for sensory nerve conduction threshold testing, which considered both the Neurometer and the Medi-Dx 7000™ device (Neuro Diagnostic Associates, Inc., Laguna Beach, CA). CMS established the following principles in assessing these devices:

The CMS document noted,

Relatively simple, non-invasive tests might have a value in the initial assessment of symptomatic patients to determine if more invasive tests are warranted. Sensory nerve conduction threshold testing is considered by some to be such a device. However, the evidence still must demonstrate that the simpler test has an acceptable level of validity otherwise it cannot reliably predict who will need more invasive tests.

Based on their extensive analysis, CMS concluded, “Based on the evidence as a whole, CMS concludes that the use of any type of sensory nerve conduction testing device … to diagnose sensory neuropathies or radiculopathies in Medicare beneficiaries is not reasonable and necessary.”

Pressure-Specified Sensory Device Testing

The Pressure-Specified Sensory Device (PSSD) is a form of QST which assesses large myelinated sensory nerve function by a computer-based form of two point discrimination testing. There is insufficient evidence to demonstrate PSSD testing provides any further information than standard evaluation and management of individuals with potential nerve compression, disease, or damage. Standard evaluation and management consists of physical examination techniques and may include Semmes-Weinstein monofilament testing and, in some more complex cases, nerve conduction velocity testing. While PSSD may be a useful adjunct in neurosensory testing, no clinical trials were identified demonstrating the use of the PSSD resulted in earlier or more accurate diagnosis of nerve damage and improved individual outcomes. In addition, no clinical practice guidelines were found addressing the use of PSSD.

Results of two studies (Wood, 2006; Siemionow, 2006) provide limited evidence PSSD may be more sensitive than some existing tests. However, the number of individuals evaluated was small in both studies. In the former paper, only 17 individuals with diabetic ulceration or amputation and in the latter, 25 individuals with peripheral nerve dysfunction were evaluated. More robust studies are required to establish sensitivity and specificity. Additional research is needed to validate the clinical utility of PSSD in identifying individuals at risk and improving clinical outcomes as compared with standard, current care. The need for validation of reference values for normal and specific disease populations was noted.


Quantitative Sensory Testing

QST systems measure and quantify the amount of physical stimuli required for sensory perception to occur in the individual. Stimuli used in QST include touch, pressure, pain, thermal (warm and cold), vibratory, or electric current stimuli. Depending on the type of stimuli used, QST can assess small or large fiber dysfunction. QST with touch and vibration can evaluate large myelinated A alpha and A beta sensory fibers. Thermal stimuli can assess small myelinated fibers and unmyelinated sensory nerve function. Low strength alternating electrical currents of selected frequencies are also reported to selectively stimulate different axons.

QST has been used in the diagnosis and management of a variety of conditions such as diabetic neuropathy and other uremic and toxic neuropathies, as well as carpal tunnel syndrome and other nerve entrapment/compression disorders or damage.

Because QST combines the objective physical sensory stimuli with the subject’s response, it is psychophysical in nature and requires individuals who are alert, able to follow directions, and cooperative. Due to the subjective component of testing, psychological factors must be taken into consideration during testing and in evaluating test results, thus reducing the degree of objectivity QST can provide.

Sensory Nerve Conduction Threshold Testing

Sensory nerve conduction threshold testing, which also may be referred to as current perception threshold testing, involves measuring the minimal amount of transcutaneous (across the skin) electrical stimulation required to evoke a sensation in the individual. An area of the skin that corresponds to a specific nerve is tested. It is believed that the extent of nerve damage an individual has suffered can be determined by measuring the amount of electrical stimulation needed for the individual to feel the stimuli. The greater the degree of nerve damage, the greater the quantity of electrical stimulation required to trigger a response in the nerve fibers and then be perceived by the subject. Sensory nerve conduction threshold testing differs from some other forms of quantitative sensory testing (QST) in that it employs electrical stimulation to generate a response from the axons while other forms of QST use non-electrical physical stimuli of the sensory receptors being tested.

In sensory nerve conduction threshold testing, typically three different frequencies of electrical stimuli are used:

The U.S. Food and Drug Administration (FDA) has approved at least two devices for measuring the threshold for sensory nerve conduction including, but not limited to, the Neurometer Current Perception Threshold (Neurotron, Inc) and the Medi-Dx 7000 (Neuro Diagnostic Associates, Inc.). An updated version of the Medi-DX 7000 is the Neural-Scan™ (Neuro Diagnostic Associates, Inc.). The Neural-Scan is a current potential threshold test with a potentiometer.

Pressure-Specified Sensory Testing

Pressure-specified sensory testing is a method to assess nerve function by quantifying the thresholds of pressure detected with light, static, and moving touch. The Pressure-Specified Sensory Device™ (Sensory Management Services LLC, Baltimore, MD) consists of one or two blunt probes and sensitive transducers to measure and record the perception thresholds of pressure on the surface of the body in grams per square millimeter. The technique is an advanced modification of the two point discrimination methodology. The device has been used to aid in the diagnosis and assessment of nerve function, including diabetic peripheral neuropathy, carpal tunnel syndrome, and other nerve entrapment or compression syndromes, and postoperative assessment of sensory outcomes after liposuction, breast reduction mammaplasty, etc. The Pressure-Specified Sensory Device received FDA 510(k) marketing clearance in August 1994.


The following codes for treatments and procedures applicable to this document are included below for informational purposes. Inclusion or exclusion of a procedure, diagnosis or device code(s) does not constitute or imply member coverage or provider reimbursement policy. Please refer to the member's contract benefits in effect at the time of service to determine coverage or non-coverage of these services as it applies to an individual member.

When Services are Investigational and Not Medically Necessary:
For the following procedure codes, or when the code describes a procedure indicated in the Position Statement section as investigational and not medically necessary.




Quantitative sensory testing (QST), testing and interpretation per extremity; using touch pressure stimuli to assess large diameter sensation


Quantitative sensory testing (QST), testing and interpretation per extremity; using vibration stimuli to assess large diameter fiber sensation


Quantitative sensory testing (QST), testing and interpretation per extremity; using cooling stimuli to assess small nerve fiber sensation and hyperalgesia


Quantitative sensory testing (QST), testing and interpretation per extremity; using heat-pain stimuli to assess small nerve fiber sensation and hyperalgesia


Quantitative sensory testing (QST), testing and interpretation per extremity; using other stimuli to assess sensation






Current perception threshold\sensory nerve conduction test (SNCT), per limb, any nerve



ICD-10 Diagnosis



All diagnoses


Peer Reviewed Publications:

  1. Chong PS, Cros DP. AAEM Practice Topic in Electrodiagnostic Medicine. American Association of Electrodiagnostic Medicine. Technology literature review: Quantitative sensory testing. Muscle Nerve. 2004; 29(5):734-747. Available at: Accessed on September 11, 2017.
  2. Freeman R, Chase KP, Risk MR. Quantitative sensory testing cannot differentiate simulated sensory loss from sensory neuropathy. Neurology. 2003; 60(3):465-470.
  3. Nogueira MP, Paley D, Bhave A, et al. Nerve lesions associated with limb-lengthening. J Bone Joint Surg Am. 2003; 85-A(8):1502-1510.
  4. Hubscher M, Moloney N, Leaver A, et al. Relationship between quantitative sensory testing and pain or disability in people with spinal pain – a systemic review and meta-analysis. Pain. 2013; 154(9):1497-1501.
  5. Radoiu H, Rosson GD, Andonian E, et al. Comparison of measures of large-fiber nerve function in patients with chronic nerve compression and neuropathy. J Am Podiatr Med Assoc. 2005; 95(5):438-445.
  6. Siao P, Cros DP. Quantitative sensory testing. Phys Med Rehabil Clin N Am. 2003; 14(2):261-286.
  7. Siemionow M, Zielinski M, Sari A. Comparison of clinical evaluation and neurosensory testing in the early diagnosis of superimposed entrapment neuropathy in diabetic patients. Ann Plast Surg. 2006; 57(1):41-49.
  8. Sorensen L, Molyneaux L, Yue DK. The level of small nerve fiber dysfunction does not predict pain in diabetic neuropathy: a study using quantitative sensory testing. Clin J Pain. 2006; 22(3):261-265.
  9. Technology Review: the Neurometer Current Perception Threshold (CPT). AAEM Equipment and Computer Committee. American Association of Electrodiagnostic Medicine. Muscle Nerve. 1999; 22(4):523-531.
  10. Vuilleumier PH, Biurrun Manresa JA, Ghamri Y, et al. Reliability of quantitative sensory tests in a low back pain population. Reg Anesth Pain Med. 2015;40(6):665-673.
  11. Wood WA, Wood MA, Werter SA, et al. Testing for loss of protective sensation in patients with foot ulceration: a cross-sectional study. J Am Podiatr Med Assoc. 2005; 95(5):469-474.

Government Agency, Medical Society, and Other Authoritative Publications:

  1. Centers for Medicare and Medicaid Services. National Coverage Determination. Sensory Nerve Conduction Threshold Tests (sNCTs). NCD# 160.23. Effective 4/1/2004. Available at: Accessed on September 11, 2017.
  2. Centers for Medicare and Medicaid Services. Decision Memorandum. Reconsideration of National Coverage Determination: Sensory Nerve Conduction Threshold Testing. July 18, 2003. Available at: Accessed on September 11, 2017.
  3. Chong PS, Cros DP. American Association Of Electrodiagnostic Medicine Review: Quantitative sensory testing equipment and reproducibility studies. 2004b. Available at: Accessed on September 11, 2017.
  4. Shy ME, Frohman EM, So YT, et al. Quantitative sensory testing: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Reaffirmed 2013. Neurology. 2003; 60(6):898-904.

Current Perception Threshold Testing
Medi-Dx 7000
Pressure-Specified Sensory Device Testing
Sensory Nerve Conduction Threshold Testing
VsNCT (Voltage-Actuated Sensory Nerve Conduction Threshold)

The use of specific product names is illustrative only. It is not intended to be a recommendation of one product over another, and is not intended to represent a complete listing of all products available.

Document History






Medical Policy & Technology Assessment Committee (MPTAC) review. The document header wording updated from “Current Effective Date” to “Publish Date.” Updated References section.



MPTAC review. Updated Rationale and References sections.



MPTAC review. Updated Description, Rationale and References. Removed ICD-9 codes from Coding section.



MPTAC review. Updated Description and References.



MPTAC review. Updated Websites.



MPTAC review. Description, Rationale, Background and Websites Updated.



MPTAC review. Updated References and Websites.



MPTAC review. Updated Index, References and Websites.



MPTAC review. References updated.



MPTAC review. References updated.



MPTAC review. The phrase “investigational/not medically necessary” was clarified to read “investigational and not medically necessary.” References updated.



MPTAC review. Title Sensory Nerve Perception Threshold Testing changed to Quantitative Sensory Testing. Pressure-specified sensory device testing added to the policy. Rationale and references updated.



Added “VsNCT (Voltage-Actuated Sensory Nerve Conduction Threshold)” to Index



MPTAC review.



Added reference for Centers for Medicare and Medicaid Services (CMS) – National Coverage Determination (NCD).



MPTAC review. Revision based on Pre-merger Anthem and Pre-merger WellPoint Harmonization.

Pre-Merger Organizations

Last Review Date

Document Number


Anthem, Inc.


Memo 1170

Current Perception Threshold Testing

WellPoint Health Networks, Inc.


Policy 2.10.18

Sensory Nerve Perception Threshold Testing