Medical Policy

Subject: Endothelial Keratoplasty
Document #: SURG.00108 Current Effective Date:    03/29/2017
Status: Reviewed Last Review Date:    02/02/2017


This document addresses a variety of endothelial keratoplasty (EK) techniques, also known as posterior lamellar keratoplasty, used to treat conditions affecting the cornea. The available EK procedures include: Descemet's membrane endothelial keratoplasty (DMEK), Descemet's stripping endothelial keratoplasty (DSEK), Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet's membrane automated endothelial keratoplasty (DMAEK). Other similar procedures addressed in this document include Femtosecond Laser-Assisted Corneal Endothelial Keratoplasty (FLEK or FLAK) or Femtosecond and Excimer Lasers-Assisted Endothelial Keratoplasty (FELEK). These procedures differ from each other in the manner in which the recipient's endothelium is removed and the methods used to prepare the donor tissue.

Note: Please see the following related documents for additional information:

Position Statement

Medically Necessary:

The use of DMEK, DSEK, DSAEK and DMAEK, is considered medically necessary for the treatment of disorders of the corneal endothelium, including but not limited to the following:

  1. Fuchs' endothelial dystrophy;
  2. Aphakic and pseudophakic bullous keratopathy (corneal edema following cataract extraction);
  3. Failure or rejection of a previous corneal transplant.

Investigational and Not Medically Necessary:

The use of DMEK, DSEK, DSAEK and DMAEK is considered investigational and not medically necessary to treat disease or injury of the corneal stroma (for example, keratoconus, corneal ulcers caused by infection and traumatic corneal injuries).

The use of FLEK or FELEK is considered investigational and not medically necessary for all indications.


Corneal endothelial failure may result in impairment or loss of vision. Restoration of vision with corneal transplantation, also known as penetrating keratoplasty (PK or PKP) has been the standard of care to treat diseased or damaged corneal endothelial tissue and stroma. However, PK has been associated with long healing time and significant complications such as postoperative dehiscence and astigmatism. Alternatives to standard corneal transplantation are being used for those diagnosed with various types of endothelial failure or endothelial dysfunction such as Fuchs's endothelial dystrophy, pseudophakic/aphakic bullous keratopathy, and failed prior corneal transplant. The use of newer EK procedures, including DSEK, DSAEK, DMEK, and DMAEK has been proposed for the treatment of non-functioning corneal endothelium related to these conditions. DSEK, DSAEK and DMAEK are procedures which utilize a partial-thickness corneal transplant involving primarily the transplantation of corneal endothelial cells. A much smaller incision is needed for these procedures compared to PK, and the graft is maintained in place while healing with a gas tamponade (bubble) rather than sutures as in the full-thickness graft used in PK.

As a result of a much smaller and peripheral incision, case series have demonstrated visual recovery following DSEK/DSAEK/DMEK can be achieved more quickly (less than 6 months) compared to PK (12-18 months) (Bahar, 2008; Chen, 2008a; Price, 2009). DSEK and DSAEK compare favorably with PK with respect to the proportion of individuals who achieve 20/40 vision postoperatively. In a prospective case series of 100 eyes by Chen and colleagues (2008a), DSEK and DSAEK resulted in improved vision, corneal thickness and surface regularity. Excluding 26 eyes with known retinal pathology, 97% of the 94 eyes had a vision of 20/40 or better at 6 months and 14% obtained visual acuity of 20/20 or better. The authors concluded that this newer technique of EK yields many of the benefits of its predecessor (PK) and improves visual results, while noting the importance of additional research to determine the safety of DSAEK.

In 2013, van Dijk and colleagues reported results of a case series study of 248 subjects (300 eyes) who underwent DMEK for Fuchs endothelial dystrophy, bullous keratopathy or previous corneal transplant failure. At 6 months, 98% of eyes reached a Best Spectacle Corrected Visual Acuity (BSCVA) of ≥ 20/40, 79% reached ≥ 20/25, 46% reached ≥ 20/20, and 14% ≥ 20/18. Donor endothelial cell density showed a decrease from 2561 (± 198) cells/mm2 before, to 1674 (± 518) cells/mm2 at 6 months after surgery (n=251; p<0.0000).

Guerra and colleagues (2011) reported on the use of DMEK in 136 eyes in 112 subjects with Fuchs' endothelial dystrophy, pseudophakic bullous keratoplasty, or failed previous graft. They reported that at 1 year, 41% of subjects achieved a BSCVA of 20/20 or better; 80% could be corrected to 20/25 or better, and 98% achieved 20/30 or better vision. A slight refractive hyperopic shift was found at 1 year, but it was not statistically significant (p=0.08). Also, there was no significant change in the preoperative astigmatism (p=0.17). Endothelial cell loss at 1 year was 36 ± 20% (n=94; range, 13%-88%), with most of the loss being observed during the first 3 months after surgery. A total of 11 grafts (8%) demonstrated primary failure and 1 eye (0.7%) had secondary failure resulting from endothelial rejection. Episodes of immunologic rejection were documented in 7 eyes (5.1%) during the first year of follow-up. The authors concluded that DMEK had better visual acuity results in the first year after surgery than typically reported for other EK techniques, such as Descemet's stripping automated EK, while having less refractive changes and similar endothelial cell counts but required a higher re-bubbling rate.

A retrospective case series of DSAEK performed on 118 eyes in 99 subjects reported complications including graft detachment, graft failure, graft rejection, cystoid macular edema, and suprachoroidal hemorrhage (Suh, 2008). The most frequent complication was graft detachment. A total of 27 eyes developed graft detachment; 25 eyes underwent a second procedure with repositioning or rebubbling after surgery, or both. Of the 118 procedures, 21 failed due to ongoing edema post-DSAEK. As noted below, with experience and improvements with DSAEK there are fewer complications reported in recent case series.

A published study by Bahar and colleagues (2008) provided the first prospective comparison of DSEK, DSAEK, DLEK and PK from a single center. This nonrandomized comparison reported on 177 eyes in 161 subjects with a mix of endothelial corneal diseases who underwent either PK (n=48), DLEK (n=68), DSEK (n=16) or DSAEK (n=45). Postoperative BSCVA outcome at 12 months for PK, DLEK, and DSEK and at 6 months for DSAEK were compared. DSAEK was measured at 6 months because of earlier stability of refraction postoperatively in this group. The BSCVA was 20/53 in the PK group, with DSAEK significantly better than PK (mean BCVA 20/44; p=0.001). DSAEK visual outcome was not significantly different from DSEK (20/56), but was better than DLEK (20/80; p=0.001). Although this study lacked randomization, the results are consistent with other case series using historic control showing DSEK/DSAEK provides earlier post-operative visual recovery, less post-surgical (sutured incision) astigmatism, and as good or better BSCVA than PK.

Although PK provides healthy donor endothelial tissue, it also replaces the overlying normal corneal stroma in individuals with disease limited to the endothelial layer. The full-thickness graft used in PK is secured with suture resulting in irregular astigmatism post operatively, often leading to the need for further corneal surgery or use of hard contact lens for visual recovery. Bahar (2008) compared postoperative astigmatism following PK, DSEK and DSAEK in a prospective, comparative nonrandomized study. Postoperative refractive astigmatism was significantly higher in the PK group (3.78 diopters) compared with DSEK (1.86 diopters) and DSAEK (1.36 diopters).

Traumatic globe rupture is a significant risk following PK and visual recovery following traumatic globe rupture is poor. In one case series by Tran and colleagues (2005), only 27% were able to recover visual acuity of 20/200 or better following attempts to repair the globe. Since both DSEK and DSAEK require a much smaller incision to introduce the endothelial graft than the sutured incision needed for a full-thickness corneal graft used in PK, the structural integrity of the globe is felt to be better maintained post operatively. A recent case-control series compared the incidence of traumatic globe rupture following PK (5.8%) with traumatic rupture rates for extracapsular cataract surgery 1/221 (0.45%) and 0/6450 for phacoemulsification. Both of these rates were significantly less than after PK (p=0.005, p<0.0001). With PK, the highest risk period for traumatic globe rupture is the month following surgery, when wound strength is derived almost entirely from sutures. The month following removal of sutures is a second high-risk period. Following PK, the cornea never regains its preoperative strength and remains at risk for traumatic rupture for the remainder of the individual's life (Elder, 2004). In contrast, there have been no reports of traumatic wound failure after DSEK/DSAEK surgery.

Graft dislocation is the most common significant risk of DSEK/DSAEK and may increase the risk of graft failure. However, most cases of dislocation can be corrected with repositioning of the graft and gas tamponade (bubble) in an office-based procedure. Recent case series report graft dislocation rates of 1-15%. In a comparative trial (Bahar, 2008), graft dislocation rates were 12.5% for DSEK and 15.6% for DSAEK. In this series, acute rejection rates were 4.2%, 0% and 2.2% for PK, DSEK and DSAEK, respectively and primary graft failure rates were 2.1%, 0%, and 2.2% for PK, DSEK, and DSAEK, respectively. These rates of acute rejection and primary graft failure were not significantly different between PK and DSEK/DSAEK.

Initial endothelial cell loss after DSEK/DSAEK is of concern and under study. In some, but not all case series it has been found to be higher with DSEK/DSAEK than PK. However, in the Bahar 2008 comparative series, endothelial cell loss 1 year after surgery was similar in the DSEK/DSAEK and PK groups (40%). More recently, larger incision sizes (5 mm rather than 3 mm) and improved insertion techniques have resulted in lower initial endothelial cell loss than reported in early studies (Chen, 2008b). In addition, the DSEK/DSAEK graft is larger (7.5-8.0 mm vs. 8.5-9.0 mm) than the PK graft which does compensate for early cell loss. A prospective case series by Price and colleagues (2010) evaluated outcomes in DSAEK (n=173) in comparison to PK (n=410) from the Cornea Donor Study. The surgeons used donor tissue between 8.25 mm and 9.0 mm with incision size of 3.2 mm or 5 mm. The author concluded,

Descemet's stripping automated endothelial keratoplasty performed by experienced surgeons resulted in a higher 6-month and 12-month percent cell loss than PKP with comparable graft survival and comparable donor and recipient characteristics. Longer-term graft success and cell loss data involving DSAEK surgeons with varying experience are needed, using a central reading center to ensure accurate and nonbiased determination of endothelial cell density.

The 3-year results of this trial were published in 2013 (Price, 2013). The 3-year survival rate of the grafts did not differ significantly between DSAEK and PK procedures performed for either Fuchs' dystrophy (96% for both; p=0.81) or non-Fuchs' cases (86% vs. 84%; p=0.41). The 3-year predicted probability of a rejection episode was 9% with DSAEK versus 20% with PK (p=0.0005). The median 3-year cell loss in Fuchs' dystrophy cases for DSAEK and PK were 46% and 51%, respectively (p=0.33), and in the non-Fuchs' cases 59% and 61%; (p=0.70). The authors concluded that graft success rate and endothelial cell loss were comparable at 3 years for DSAEK and PK procedures and that a 5-mm DSAEK incision width was associated with significantly less cell loss than a 3.2-mm incision.

The advantages of DSEK/DSAEK cited above (little if any globe rupture, earlier post-operative visual recovery, and less post-surgical astigmatism), have led to their rapid adoption over PK for the treatment of corneal endothelial failure. According to the Eye Bank Association of America (EBAA) Statistical Report (2014), more than half (54.6%) of corneal transplants performed in 2014 in the United States (U.S.) were endothelial grafts; exceeding the number of PK procedures for the third consecutive year. EK is currently the most commonly performed keratoplasty in the U.S. Although the advantages of EK procedures over PK have yet to be demonstrated in large, randomized controlled trials, evidence from a growing body of case series studies is compelling and has resulted in the rapid adoption of these newer techniques for treating corneal endothelial disease.

The American Academy of Ophthalmology (AAO) released a report in 2009 entitled "Descemet's Stripping Endothelial Keratoplasty: Safety and Outcome". The conclusions of the report include:

The evidence reviewed is supportive of DSEK being a safe and effective treatment for endothelial diseases of the cornea. In terms of surgical risks, complication rates, graft survival (clarity), visual acuity, and endothelial cell loss, DSEK appears similar to penetrating keratoplasty (PK). It seems to be superior to PK in terms of earlier visual recovery, refractive stability, postoperative refractive outcomes, wound and suture-related complications, and intraoperative and late suprachoroidal hemorrhage risk. The most common complications of DSEK do not appear to be detrimental to the ultimate vision recovery in most cases. Long-term endothelial cell survival and the risk of late endothelial rejection are beyond the scope of this assessment.

A 2014 Cochrane review of PK versus EK as treatment for Fuchs endothelial dystrophy analyzed three RCTs representing a total 123 eyes and did not find evidence of improved visual recover after EK procedures and although higher order aberrations were lower in EK recipients, endothelial cell loss was greater. Authors acknowledge that the overall quality of the trials chosen for inclusion were not satisfactory given their small sample size and unmasked design. The review concluded that:

More RCTs are needed to compare PKP with commonly performed EK procedures such as DSEK, DSAEK and DMEK in order to determine the answers to two key questions, whether there is any difference in the final visual outcome between these techniques and whether there are differences in the rates of graft survival in the long term?

A long-standing corneal transplant registry in Australia has provided long-term prospective data for a large cohort of 13,920 PKs, 88 DLEKs, and 2287 EKs performed between 1996 and 2013 (Coster, 2014). The primary outcome of interest in this cohort study was graft survival. Using Kaplan-Meier functions, investigators found that survival of EKs performed for Fuchs' dystrophy or pseudophakic bullous keratopathy were poorer than survival of PKs for the same indications over the same time-frame (p<0.001). Visual outcomes were significantly better for PKs than for EK performed for Fuchs' dystrophy (p<0.001), but EKs achieved better visual outcomes than PKs for pseudophakic bullous keratopathy (p<0.001). Authors conclude that the primary outcome, graft failure, favored PK for longevity. Given the poor outcomes seen following graft failure, including increased risk for subsequent graft failure (Mitry, 2014) more long-term data from randomized, controlled-trials are needed to further define the long-term efficacy of EK compared to the more traditional PK approach. A major-shortcoming of this study design that warrants caution when interpreting results, is its failure to differentiate results by the type of EK technique performed (i.e., DSEK, DSAEK, DMEK, or DMAEK).

Two more recent EK techniques to be developed, called FLEK or FLAK and FELEK, utilize laser techniques to prepare the donor tissue for transplantation as opposed to manual methods used for other EK procedures. The literature addressing this procedure is limited. Cheng (2009) reported the results of a randomized trial comparing FLEK with PK for 80 subjects (80 eyes) with Fuchs' endothelial dystrophy, pseudophakic bullous keratopathy, or posterior polymorphous dystrophy, and best spectacle-corrected visual acuity less than 20/50. Subjects were randomly assigned in a 1:1 manner. In the FLEK group, 4 of the 40 eyes which did not receive the procedure were excluded from the analysis. A total of 8 eyes failed (22% of 36), and 2 participants were lost to follow-up due to death. In the PK group, only 1 participant was lost to follow-up. At 12 months postoperatively, refractive astigmatism was lower in the FLEK group than the PK group (86% vs. 51%), but there was greater hyperopic shift. Mean BSCVA was better following PK than FLEK at 3-, 6-, and 12-month follow-up. Endothelial cell loss was reported as greater in the FLEK group (65%) versus the PK group (23%). With the exception of dislocation and need for repositioning of the FLEK grafts in 28% of eyes, the percentage of complications were similar in the 2 groups. Complications in the FLEK group were due to pupillary block, graft failure, epithelial ingrowth, and elevated intraocular pressure, whereas complications in the PK group were related to the sutures and elevated intraocular pressure. The authors concluded that FLEK effectively reduced postoperative astigmatism and eliminated wound healing related problems compared to PK. However, they note that visual acuity is lower compared with conventional PK, and the rate of endothelial cell loss warrants further investigation.

A non-randomized retrospective comparative study by Chamberlain (2013) involving 100 subjects compared FLEK (n=50) to PK (n=50). Significantly lower topographic astigmatism was achieved in the FLEK group over the PK group in the 4- to 6-month follow-up period (p=0.0324). However, this difference was not present in any other follow-up period up to 24 months postoperatively. A subset analysis of subjects with keratoconus or post-LASIK ectasia did not show any difference in either astigmatism or visual acuity at any time. No significant improvement in BSCVA was noted at any time point.

Cheng (2011) reported a prospective, randomized clinical trial involving 80 subjects (80 eyes) with corneal endothelial dysfunction randomized to undergo FLEK or PK. At the end of 12 months, only 29 (72.5%) FLEK subjects were available for analysis versus 39 (97.5%) in the PK group. In the FLEK group, postoperative refractive and topographic astigmatism values were not significantly different from preoperative values. In the PK group, all postoperative refractive and topographic astigmatism values were significantly higher compared with those before surgery. At 12 months after surgery, the percentage of subjects with a refractive astigmatism of ≤ 3.0 diopters was significantly higher in the FLEK group compared with the PK group (86.2% vs. 51.3%; p=0.004). Post-operatively, the mean BSCVA in the PK group was significantly better when compared with the FLEK group at all follow-up visits. The mean gain in BSCVA at 12 months was not significantly different between the FLEK and PK groups (p=0.103).

A small (n=22) retrospective cohort study from 2013 reported a reduction in visual acuity when the endothelial transplant was prepared with FLEK versus DSAEK (Vetter, 2013). There was also greater surface irregularity with the laser-assisted EK. Given this data, it is unclear that there is any benefit to FLEK, and it may be deduced by the available evidence that PK may be superior to FLEK with regard to postoperative visual acuity.

There are no studies available in the peer-reviewed published literature addressing the use of FELEK. Until such data is available, the safety and efficacy of this procedure is uncertain.


According to the National Eye Institute (NEI), approximately 40,000 PKs, also known as corneal transplants, are performed each year in the U.S. A corneal transplant is commonly performed to replace scarred or diseased cornea. The central portion of a cloudy cornea is removed and replaced with a donor cornea. The donor cornea is sewn in place and the suture remains in place for months to allow the graft to heal properly. After the procedure, eye drops may be used for several months to assist with the healing process. Full recovery from a PK may take up to a year or longer.

EK techniques are used to treat a variety of conditions affecting the cornea. Available EK procedures include DMEK, DSEK, DSAEK and DMAEK. DMEK, DSEK, DSAEK, and DMAEK are lamellar (non-penetrating keratoplasty) procedures in which only a portion or partial-thickness of the cornea is removed. These techniques have been developed as an alternative to PK, which involves the replacement of the full-thickness of the recipient cornea with donor cornea. PK has been associated with long healing time and significant complications such as postoperative dehiscence and astigmatism. In contrast, EK techniques replace only the diseased corneal endothelium and involve removal of Descemet's membrane (basement layer positioned between the outer corneal stroma and the inner corneal endothelial layer) and diseased endothelium from the recipient cornea. Healthy cadaveric donor corneal endothelial tissue, including Descemet's membrane and a thin layer of donor stromal tissue, are harvested and implanted into the recipient's eye. The various procedures differ in the methods used to prepare the donor cornea and the ways the recipient epithelium is removed.

Two additional EK procedures, FLEK and FELEK expand on the EK procedures addressed above by using laser cutting tools for intrastromal dissection of the donor tissue prior to removal. This is proposed to provide an improved wound stability and decreased postoperative astigmatism.


Aphakia: The absence of the natural crystalline lens.

Cornea: The outermost layer of the eye; dome shaped and covers the front of the eye.

Epithelium: The outermost layer of tissue.

Phakia: The presence of the natural crystalline lens.

Pseudophakia: The substitution of the natural crystalline lens with a synthetic lens.


The following codes for treatments and procedures applicable to this document are included below for informational purposes. Inclusion or exclusion of a procedure, diagnosis or device code(s) does not constitute or imply member coverage or provider reimbursement policy. Please refer to the member's contract benefits in effect at the time of service to determine coverage or non-coverage of these services as it applies to an individual member.

When services are Medically Necessary when procedure is specified as DMEK, DMAEK, DSEK, DSAEK:

65756 Keratoplasty (corneal transplant); endothelial
65757 Backbench preparation of corneal endothelial allograft prior to transplantation
ICD-10 Procedure  
  For the following codes when specified as endothelial keratoplasty DMEK, DMAEK, DSEK, DSAEK:
08R83KZ Replacement of right cornea with nonautologous tissue substitute, percutaneous approach
08R93KZ Replacement of left cornea with nonautologous tissue substitute, percutaneous approach
ICD-10 Diagnosis  
  Including, but not limited to, the following diagnoses:
H18.10-H18.13 Bullous keratopathy
H18.20-H18.239 Other and unspecified corneal edema
H18.331-H18.339 Rupture in Descemet's membrane
H18.51 Endothelial corneal dystrophy (Fuchs' endothelial dystrophy)
H18.59 Other hereditary corneal dystrophies
T85.29XA-T85.29XS Other mechanical complication of intraocular lens
T86.840 Corneal transplant rejection
T86.841 Corneal transplant failure
T86.848 Other complications of corneal transplant

When services are Investigational and Not Medically Necessary:
For the procedure codes listed above specified as DMEK, DMAEK, DSEK, DSAEK, for the following diagnoses:

ICD-10 Diagnosis  
H16.001-H16.079 Corneal ulcer
H17.00-H17.9 Corneal scars and opacities
H18.50 Unspecified hereditary corneal dystrophies
H18.52 Epithelial (juvenile) corneal dystrophy
H18.53 Granular corneal dystrophy
H18.54 Lattice corneal dystrophy
H18.55 Macular corneal dystrophy
H18.601-H18.629 Keratoconus
H18.711-H18.799 Other corneal deformities (corneal ectasia, corneal staphyloma, descemetocele, other)
H18.831-H18.839 Recurrent erosion of cornea
H18.9 Unspecified disorder of cornea
S05.00XA-S05.02XS Injury of conjunctiva and corneal abrasion without foreign body

When services are also Investigational and Not Medically Necessary:
For the procedure codes listed above specified as FLEK/FLAK or FELEK for all diagnoses, or when the code describes a procedure indicated in the Position Statement section as investigational and not medically necessary.


Peer Reviewed Publications:

  1. Allan BD, Terry Ma, Price FW, et al. Corneal transplant rejection rate and severity after endothelial keratoplasty. Corneal. 2007; 26(9):1039-1042.
  2. Bahar I, Kaiserman I, McAllum P, et al. Comparison of posterior lamellar keratoplasty techniques to penetrating keratoplasty. Ophthalmology. 2008; 115(9):1525-1533.
  3. Chamberlain WD, Rush SW, Mathers WD, et al. Comparison of femtosecond laser-assisted keratoplasty versus conventional penetrating keratoplasty. Ophthalmology. 2011; 118(3):486-491.
  4. Chen ES, Terry MA, Shamie, N, et al. Descemet-stripping automated endothelial keratoplasty: insertion using novel 40/60 underfold technique for preservation of donor endothelium. Cornea. 2008; 27(8):941-943.
  5. Chen ES, Terry MA, Shamie N, et al. Descemet-stripping automated endothelial keratoplasty: six-month results in a prospective study of 100 eyes. Corneal. 2008a; 27(5):514-520.
  6. Cheng YY, Schouten JS, Tahzib NG, et al. Efficacy and safety of femtosecond laser-assisted corneal endothelial keratoplasty: a randomized multicenter clinical trial. Transplantation. 2009; 88(11):1294-1302.
  7. Cheng YY, van den Berg TJ, Schouten JS, et al. Quality of vision after femtosecond laser-assisted descemet stripping endothelial keratoplasty and penetrating keratoplasty: a randomized, multicenter clinical trial. Am J Ophthalmol. 2011; 152(4):556-566.
  8. Chih A, Lugo M, Kowing D. Descemet stripping and automated endothelial keratoplasty: an alternative to penetrating keratoplasty. Optom Vis Sci. 2008; 85(3):152-157.
  9. Coster DJ, Lowe MT, Keane MC, et al. A comparison of lamellar and penetrating keratoplasty outcomes: a registry study. Ophthalmology. 2014; 121(5):979-987.
  10. Covert DJ, Koenig SB. Descemet stripping and automated endothelial keratoplasty (DSAEK) in eyes with failed penetrating keratoplasty. Cornea. 2007; 26(6):692-696.
  11. Elder MJ, Stack RR. Globe rupture following penetrating keratoplasty: how often, why, and what can we do to prevent it? Cornea. 2004; 23(8):776-780.
  12. Guerra FP, Anshu A, Price MO, et al. Descemet's membrane endothelial keratoplasty: prospective study of 1-year visual outcomes, graft survival, and endothelial cell loss. Ophthalmology. 2011; 118(12):2368-2373.
  13. Koenig SB, Covert DJ. Early results of small-incision Descemet's stripping and automated endothelial keratoplasty. Ophthalmology. 2007; 114(2):221-226.
  14. Mearza AA, Qureshi MA, Rostron CK. Experience and 12 month results of Descemet-stripping endothelial keratoplasty (DSEK) with a small-incision technique. Cornea. 2007; 26(3):279-283.
  15. Melles GF, Lander F, van Dooren BT, et al. Preliminary clinical results of posterior lamellar keratoplasty through a sclerocorneal pocket incision. Ophthalmology. 2000; 107(10):1850-1856.
  16. Mitry D, Bhogal M, Patel AK, et al. Descemet stripping automated endothelial keratoplasty after failed penetrating keratoplasty: survival, rejection risk, and visual outcome. JAMA Ophthalmol. 2014; 132(6):742-749.
  17. Price FW Jr, Price MO. Descemet's stripping with endothelial keratoplasty in 200 eyes: early challenges and techniques to enhance donor adherence. J Cataract Refract Surg. 2006: 32(3):411-418.
  18. Price MO, Fairchild KM, Price FW Jr. Comparison of manual and automated endothelial cell density analysis in normal eyes and DSEK eyes. Cornea. 2013; 32(5):567-573.
  19. Price MO, Giebel AW, Fairchild KM, Price FW Jr. Descemet's membrane endothelial keratoplasty: prospective multicenter study of visual and refractive outcomes and endothelial survival. Ophthalmology. 2009; 116(12):2361-2368.
  20. Price MO, Gorovoy M, Benetz BA, et al. Descemet's stripping automated endothelial keratoplasty outcomes compared with penetrating keratoplasty from the Cornea Donor Study. Ophthalmology. 2010; 117(3):438-444.
  21. Price MO, Price FW. Endothelial cell loss after Descemet stripping with endothelial keratoplasty influencing factors and 2-year trend. Ophthalmology. 2008; 115(5):857-865.
  22. Suh LH, Yoo SH, DeoBhakta A, et al. Complications of Descemet's stripping with automated endothelial keratoplasty: survey of 118 eyes at one institute. Ophthalmology. 2008; 115(9):1517-1524.
  23. Terry MA, Chen ES, Shamie N, et al. Endothelial cell loss after Descemet's stripping endothelial keratoplasty in a large prospective series. Ophthalmology. 2008; 115(3):488-496.
  24. Tran TH, Ellies P, Azan F, et al Traumatic globe rupture following penetrating keratoplasty. Graefes Arch Clin Exp Ophthalmol. 2005; 243(6):525-530.
  25. Trousdale ER, Hodge DO, Baratz KH, et al. Vision-related quality of life before and after keratoplasty for Fuchs's endothelial dystrophy. Ophthalmology. 2014; 121(11):2147-2152.
  26. van Dijk K, Ham L, Tse WH, et al. Near complete visual recovery and refractive stability in modern corneal transplantation: Descemet membrane endothelial keratoplasty (DMEK). Cont Lens Anterior Eye. 2013; 36(1):13-21.
  27. Vetter JM, Butsch C, Faust M, et al. Irregularity of the posterior corneal surface after curved interface femtosecond laser-assisted versus microkeratome-assisted descemet stripping automated endothelial keratoplasty. Cornea. 2013; 32(2):118-124.

Government Agency, Medical Society, and Other Authoritative Publications:

  1. Eye Bank Association of America. 2015 Eye Banking Statistical Report. Washington, DC. 2015. Available at: Accessed on January 07, 2017.
  2. Lee WB, Jacobs DS, Musch DC, et al. Descemet's Stripping Endothelial Keratoplasty: Safety and Outcomes: A Report by the American Academy of Ophthalmology. Reviewed 2014. Volume 116, Issue 9. September 2009. For additional information visit the AAO website: Accessed on January 07, 2017.
  3. Nanavaty MA, Wang X, Shortt AJ. Endothelial keratoplasty versus penetrating keratoplasty for Fuchs endothelial dystrophy. Cochrane Database Syst Rev. 2014;(2):CD008420.
Websites for Additional Information
  1. National Eye Institute (NEI). Facts about the cornea and corneal disease. Updated in May 2016. Available at: . Accessed on January 07, 2017.

Descemet's membrane automated endothelial keratoplasty (DMAEK)
Descemet's membrane endothelial keratoplasty (DMEK)
Descemet's stripping automated endothelial keratoplasty (DSAEK)
Descemet's stripping endothelial keratoplasty (DSEK)
Endothelial keratoplasty (EK)
Femtosecond and Excimer Lasers-Assisted Endothelial Keratoplasty (FELEK)
Femtosecond Laser-Assisted Corneal Endothelial Keratoplasty (FLEK or FLAK)
Partial-thickness, corneal transplant

Document History




Reviewed 02/02/2017 Medical Policy & Technology Assessment Committee (MPTAC) review. Updated References section.
Reviewed 02/04/2016 MPTAC review. Updated Rationale and Reference sections. Removed ICD-9 codes from Coding section.
Reviewed 02/05/2015 MPTAC review. Updated Description/Scope, Rationale, and Reference sections.
Revised 02/13/2014 MPTAC review. Restructured existing position statements. Added DMEK and DMAEK as medically necessary. Added the use of FLEK or FELEK as investigational and not medically necessary. Revised Scope, Updated Rationale, Background, Coding, Index and Reference sections.
Reviewed 02/14/2013 MPTAC review. Updated Rationale, References and Websites.
Reviewed 02/16/2012 MPTAC review. Updated Rationale, References and Websites.
Reviewed 02/17/2011 MPTAC review. Rationale, References and Websites updated.
Reviewed 02/25/2010 MPTAC review. Rationale and references updated.
Revised 02/02/2009 MPTAC review. Interim call held. Added Medical Necessity criteria for DSEK and DSAEK. Clarified Investigational and Not Medically Necessary statement. Rationale, Coding and References updated.
New 11/20/2008 MPTAC review. Initial document development.